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trendy or anything like that, just an average pub that's quite large too. There's a trendier pub\bar called The Albany (I think) nearby. That's more cool and trendy but as I'm neither, I go to The Green Man.
The Cock and the Horse And Groom are Sam Smiths pubs and are decent.
just off Great Portland Street on Devonshire Street. Linky link: http://maps.google.co.uk/maps?q=the+masons+arms+great+portland+street&fb=1&gl=uk&hq=the+masons+arms+great+portland+street&cid=0,0,15785778134409671161&t=m&z=16&iwloc=A
that way you can sit downstairs and reminisce about the time I saw Frank Black play an intimate gig there and met Chris Morris in the same bloody night.