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which ones are the best?
My favourite is http://picturesforsadchildren.com/ it's both hilarious and soul destroying.
and questionable content, which is now really whiney and not at all funny, but i'm still strangley hooked
Dinosaur Comics - http://qwantz.com - a comic about talking dinosaurs. Also http://definingterms.com/dinoremix is really fun
Wondermark - http://wondermark.com - love the artwork on this
Nedroid Picture Diary - http://nedroid.com - endless parties
Hark! A Vagrant - http://harkavagrant.com - hilarious history sketches
I love Pictures for Sad Children but it updates far too rarely that i usually forget about it :(
I check xkcd too. It's more miss than hit these days but there are loads of GEMS in the archives.