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Manchester United's Cristiano Ronaldo may be rested for Tuesday's Champions League tie against Celtic as he is still recovering from ankle surgery.
Patrice Evra (hamstring) is definitely out so John O'Shea is set to come in.
Midfielder Marc Crosas did not travel with Celtic's squad after suffering an injury in Saturday's win at Inverness, but Andreas Hinkel has made the trip.
Jan Vennegoor of Hesselink, Georgios Samaras and Chris Killen are out, but Gary Caldwell is expected to play.
United, meanwhile, can welcome Carlos Tevez and Anderson back from international duty, although Michael Carrick and Owen Hargreaves are still missing.
And manager Sir Alex Ferguson is keen to give Ronaldo time to fully recover from the summer surgery on his ankle.
After a conversation with former United assistant and current Portugal boss Carlos Queiroz, Ferguson is tempted to bring in Nani instead.
"Carlos feels Cristiano is still finding it hard to recover from a Saturday game to a Wednesday," said Ferguson.
"I need to look at this game - and the fact it is on a Tuesday - and assess whether to bring in Nani."
Evra tweaked a hamstring during Saturday's win over West Brom.
He did some light jogging at United's Carrington training ground on Monday morning, but Ferguson decided not to take a chance on his fitness.
Celtic's Caldwell, who did not join in with full training on Monday, was substituted during the 2-1 win over Inverness Caledonian Thistle on Saturday, but Celtic manager Gordon Strachan says the Scotland defender is determined to play, despite having stitches in his foot following the match.
Ferguson expects Celtic to 'have a go'
"He has a determined streak through him - he really shouldn't have gone back on at half-time on Saturday," said Strachan.
"But knowing Gary, he wanted to win the game at Inverness and wanted to make sure he's still playing.
"On the team bus going back on Saturday night I tried to pick a team that told him he was still in my thoughts.
"I know Gary, and if he can be there, he'll be there."
It is up front where Celtic have most problems, with Samaras requiring a cartilage operation after being injured on international duty with Greece and having missed the trip to the Highlands.
With Netherlands striker Vennegoor of Hesselink and New Zealander Killen already sidelined, it leaves Scott McDonald as the only fit out-and-out first-team striker available to Strachan.
Manchester United (from): Van der Sar, Kuszczak, Brown, Neville, Rafael, Ferdinand, Vidic, Evans, O'Shea, Ronaldo, Nani, Fletcher, Anderson, Giggs, Gibson, Park, Tevez, Berbatov, Rooney, Manucho.
Celtic (from): Boruc, Caldwell, Wilson, McManus, Loovens, Naylor, McGeady, S Brown, Hinkel, Hartley, Robson, McDonald, Sheridan, Maloney, M Brown, McCourt, Hutchinson, Nakamura, O'Dea.
They signed in January. Hasn't played competitively yet, I think
i hate the scum, but i can't see this going any other way but rooney putting about 12 past celtic.
should be a good match anyhow.
rooney has had a spell of six good games after two years of being a shade above dreadful..its not going to last forever.
I can't see Celtic putting up a challenge.
most of the rest are cunts.
say Rooney has been a shade above dreadful, sure people expect more of him but he has held United together in a lot of games and although he's not scored many, he plays well in most games.
700/1 on Celtic winning 0-3
might have a cheeky bet on 3-1
this is going to happen.
The new Van Nistlerooy. In that offside doesn't really seem to apply to him.