This is of course a pointless football question that'll only serve to cause silly arguments.
Until recently Hull was the biggest city in the country to have not had a top-flight football team. This changed with their play-off win. However Bristol City's defeat left Bristol as the biggest city in the country to have never had a Premier League team.
But my question is this and it's entirely subjective and open to definition:
Which team do you think is the biggest team in the country not to have so far played (or to be playing next season) in the English Premier League?
My answer's Preston North End incidentally.