New film with Samuel L Jackson. Title explains plot.

From an online interview with Samuel L.:

Beaks: One of those films that you're working on right now is... well, it's called "Pacific Air 121"

Jackson: Snakes on a Plane, man!

Beaks: Exactly.

Jackson: We're totally changing that back. That's the only reason I took the job: I read the title.

Beaks: Snakes on a Plane! That's everything!

Jackson: You either want to see that, or you don't.

Snakes on a muthafuckin' plane!

I can't wait.