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Actors who have had two (or more) career-defining roles
Most actors are lucky to get one role that ensures their fame, fortune, and cinematic legacy, and I can't think of many that get two.
In fact, the only person that springs to mind is Harrison Ford - he would be remembered forever for being Han Solo OR Indiana Jones - having both is just greedy.
Who else has done it twice? Name them and I will dismiss them out of hand.