DC may refer to:

• District of Columbia, also known as Washington, D.C., the capital of the United States
• Distrito capital, the capital district of a Spanish-speaking nation
  • Bogotá, D.C., the capital of Colombia

• Douglas Aircraft Company
• dc (computer program)
• Device Context, a programming object within the Microsoft Windows API
• Direct Connect (file sharing), a peer-to-peer file sharing protocol
• Distributed computing
• Domain controller, a Microsoft Windows server that responds to security authentication requests
• Dublin Core, a metadata standard
• Dynamic contrast, a technology related to LCD screens
• Domain Component, an attribute for DNS names in LDAP
• DigiCipher, a digital encoding scheme for digital television
• DCxx, product code for all Dyson vacuum cleaners.
• DC-frames or DC-pictures, type of frames/pictures in MPEG

• Direct current, the unidirectional flow of electric charge
• DC offset, the mean amplitude of a waveform
• DC bias, the mean value of a waveform in regard to a periodic function in the frequency domain

• Dendritic cell, a type of immune cell
• Doctor of Chiropractic

• D.C. (TV series)
• DC Comics, a comic book publisher
• DC Recordings, a record label
• The Deccan Chargers, a cricket team which represents hyderabad in the Indian Premier League
• Da capo, a musical term
• Da Capo (visual novel)
• Dark Cloud, a video game series
• Dashboard Confessional, an American rock band
• Dane Cook, American comedian whose self-given nickname is DC
• David Cook (singer), winner of the seventh season of American Idol
• The Deccan Chronicle, a newspaper
• Destiny's Child, a musical group
• Detective Conan, a manga also known as Case Closed
• Discovery Channel
• Disney Channel
• The Dixie Chicks, a country music group
• Dreamcast, a video game console
• Drum Connection, a German musical group

• D. C. Fontana (b. 1939), screenwriter
• David Coulthard (b. 1971), British racing driver
• A. P. de Candolle (1778-1841), a botanist abbreviated as DC in botanical nomenclature
• Dave Chappelle, African-American comedian

• DC Shoes, a footwear company
• Detective Constable, rank in the British police
• Deputy Commissioner of Police of the Metropolis, London Metropolitan Police Service senior rank
• Deccan Chargers, an Indian cricket franchise
• Defined contribution, a type of pension plan
• Dené-Caucasian, a language family
• Developed country
• Distribution center
• Axiom of dependent choice, a concept in mathematics
• Dottrinari, or the Preti della Dottrina Cristiana, a Catholic organization
• Golden Air, an airline, DC in IATA code
• Dulwich College, an English secondary school
• DC, abbrevation for several Christian democratic parties throughout the world
• DC, the number 600 in Roman numerals
• DC, an Engrish abbreviation meaning "discount"
• Dossier criminal